样本编号 SAMC1471527
外部数据库编号 GSA-Human: HRS094317
样品名称 NM_02_121
样本标题 kidney cancer patents paracancerous tissues
样品类型 Human sample
物种名称 Homo sapiens
描述信息 polyA RNA
样本属性 *该样本包含更多受控访问信息,请通过GSA-Human系统申请项目HRA000342数据获取。
发布日期 2021-01-20
项目编号 PRJCA003506
提交者 Ping  Lu  (tangfuchou@pku.edu.cn)
提交单位 Peking University
提交日期 2023-06-18

样本包含数据信息

资源名称 描述
GSA-Human (1) -
HRA000342  (Controlled Access) IgA nephropathy represents the most prevalent chronic nephrosis worldwide. However, pathogenesis about IgA deposition and end-stage renal failure is still not well defined. Using single-cell RNA-seq, we identified the mesangial membrane receptor for IgA, which collaborates with increased extracellular matrix proteins and protease inhibitor to facilitate IgA deposition. Meanwhile, cell-cell interaction analysis revealed increased communications between mesangium and other cell types, uncovering how morbidity inside glomerulus spreads to whole kidney, which results in the genetic changes of kidney resident immune cells. Prominent interaction decreasing in intercalated cells leads to the discovery of a transitional cell type, which exhibited significant EMT and fibrosis features. Our work comprehensively characterized the pathological mesangial signatures, highlighting the step-by-step pathogenic process of IgA nephropathy from mesangium to epithelium.
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