| 项目编号 |
PRJCA004804 |
| 项目标题 |
Single-cell genomics study of Microevolution of colon cancer metastasis |
| 涉及领域 |
Medical |
| 数据类型 |
Exome
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Heterogeneity is an important property of tumor cells. The microevolution process of tumor cells during the period of tumorigenesis, tumor progress, and tumor metastasis plays a key role in understanding this disease. However, currently a detailed study of microevolution of tumor cells at single-cell level is still lacking. In the proposed study, we collect samples from colon cancer patients at primary location, liver metastatic location, metastatic lymph node, and blood stream circulation tumor cells. We use the latest single cell DNA and RNA sequencing technology to sequence a population of cells at each sample. Then, we develop bioinformatics methods to analyze the large data sets and build evolution models to study the molecular microevolution process of colon tumor progress. |
| 样品范围 |
Single cell |
| 发布日期 |
2021-05-24 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 34507604
|
Single-cell exome sequencing reveals multiple subclones in metastatic colorectal carcinoma
|
Genome Medicine
|
10.1186/s13073-021-00962-3
|
2021
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
Major Research Plan
|
91631111
|
|
|
|
| 提交者 |
Dan
Xie (danxie@scu.edu.cn)
|
| 提交单位 |
West China Hospital Sichuan University |
| 提交日期 |
2021-03-25 |
