样本编号 SAMC2193755
外部数据库编号 GSA-Human: HRS429597
样品名称 S88
样本标题 raw data for S88
样品类型 Human sample
物种名称 Homo sapiens
描述信息 raw data for S88
样本属性 *该样本包含更多受控访问信息,请通过GSA-Human系统申请项目HRA002757数据获取。
发布日期 2023-04-19
项目编号 PRJCA010743
提交者 Zhuo  Ma  (xutao@ibp.ac.cn)
提交单位 Institute of Biophysics, Chinese Academy of Sciences
提交日期 2023-06-18

样本包含数据信息

资源名称 描述
GSA-Human (1) -
HRA002757  (Controlled Access) Here, we performed scRNA-seq of human embryonic pancreas tissues collected from PCW 4 to 11 and scATAC-seq from PCW 8 to 11. We profiled the major cell types of pancreatic epithelial cells, including dorsal and ventral MP cells, and revealed their molecular heterogeneity and developmental trajectory. We analyzed the transcription factors, regulatory networks and signaling pathways of acinar and ductal lineage cells and revealed a regulatory network of endocrinogenesis and transcription dynamics of EP and endocrine cells. We further compared the developmental trajectories between humans and mice and demonstrated a few distinct features, such as gene expression patterns, in each species. Taken together, our data depict the whole progression of pancreatic organogenesis during the first trimester (PCW 4-11) at the single-cell level.
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