Accession SAMC2193715
Accession in Other Database GSA-Human: HRS429587
Sample name S14
Title raw data for S14
Sample type Human sample
Organism Homo sapiens
Description raw data for S14
Attributes *This sample record contains additional controlled-access information that is avaiable from GSA-Human by requesting study HRA002757 in the GSA-Human system.
Release date 2023-04-19
BioProject Accession PRJCA010743
Submitter Zhuo  Ma  (xutao@ibp.ac.cn)
Organization Institute of Biophysics, Chinese Academy of Sciences
Submission date 2023-06-18

Sample Data

Resource name Description
GSA-Human (1) -
HRA002757  (Controlled Access) Here, we performed scRNA-seq of human embryonic pancreas tissues collected from PCW 4 to 11 and scATAC-seq from PCW 8 to 11. We profiled the major cell types of pancreatic epithelial cells, including dorsal and ventral MP cells, and revealed their molecular heterogeneity and developmental trajectory. We analyzed the transcription factors, regulatory networks and signaling pathways of acinar and ductal lineage cells and revealed a regulatory network of endocrinogenesis and transcription dynamics of EP and endocrine cells. We further compared the developmental trajectories between humans and mice and demonstrated a few distinct features, such as gene expression patterns, in each species. Taken together, our data depict the whole progression of pancreatic organogenesis during the first trimester (PCW 4-11) at the single-cell level.
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