| Accession |
PRJCA020570 |
| Title |
Single-cell Sequencing Reveals Intra-tumoral Heterogeneity and Malignant Progression of Adrenal Incidentaloma |
| Relevance |
Medical |
| Data types |
Single cell sequencing
|
| Organisms |
Homo sapiens
|
| Description |
Adrenal incidentaloma, the most prevalent type of adrenal tumors, exhibits marked heterogeneity, giving rise to divergent clinical outcomes. This study aims to elucidate the heterogeneous tumor progression characteristics of adrenocortical and medullary adenomas. To achieve this, we employed single-cell RNA sequencing (scRNA-seq) to construct a comprehensive transcriptomic atlas comprising 49,057 individual cells obtained from 12 donors. The dataset encompassed various subtypes, including cortisol-producing adrenocortical adenomas (CPA), aldosterone-producing adenomas (APA), pheochromocytomas (PCC), and paragangliomas. |
| Sample scope |
Single cell |
| Release date |
2025-09-16 |
| Data provider |
|
| Biomaterial provider |
Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China. |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
32271165
|
|
| National Key Research and Development Program of China
|
|
2017YFA0103902
|
|
| Shanghai Municipal Key Clinical Specialty
|
|
shslczdzk00901
|
|
| Innovative Research Team of High-level Local Universities in Shanghai
|
|
SSMU-ZDCX20180700
|
|
| Key Laboratory Program of the Education Commission of Shanghai Municipality
|
|
ZDSYS14005
|
|
|
|
| Submitter |
Meng
Wang (wm19921276529@163.com)
|
| Organization |
Shanghai Jiao Tong University School of Medicine |
| Submission date |
2023-10-17 |
