| 项目编号 |
PRJCA024895 |
| 项目标题 |
CD177+ neutrophil with activated mitochondrial complex I form neutrophil extracellular traps during lung ischemia-reperfusion injury |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Primary graft dysfunction (PGD) is the leading cause of early morbidity and mortality after lung transplantation. Neutrophils play a critical role in the exacerbated inflammatory process of severe PGD caused by lung ischemia-reperfusion injury (IRI). Nevertheless, the comprehensive elucidation of neutrophil phenotypic heterogeneity remains predominantly unexplored. We performed bulk RNA-Seq of neutrophils from the paired blood samples before and after transplantation, and we also performed single RNA-Seq of neotrophils from matched lung and blood samples obtained from a patient experiencing grade 3 PGD. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-05-07 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
Targeting mitochondrial complex I of CD177+ neutrophils alleviates lung ischemia-reperfusion injury
|
Cell Reports Medicine
|
10.1016/j.xcrm.2025.102140
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Scientific and Technological Innovation action Plan of Science and Technology Commission of Shanghai Municipality
|
|
No.20DZ2253700
|
|
|
|
| 提交者 |
Chang
Chen (chenthoracic@163.com)
|
| 提交单位 |
Shanghai Pulmonary Hospital, School of Medicine, Tongji University |
| 提交日期 |
2024-04-02 |
