e.g., HRA000087; HRA000150
HRA000342
Title:
Single-Cell Transcriptomics reveals novel immune mechanisms of the onset and progression of IgA nephropathy
Release date:
2021-01-20
Description:
IgA nephropathy represents the most prevalent chronic nephrosis worldwide. However, pathogenesis about IgA deposition and end-stage renal failure is still not well defined. Using single-cell RNA-seq, we identified the mesangial membrane receptor for IgA, which collaborates with increased extracellular matrix proteins and protease inhibitor to facilitate IgA deposition. Meanwhile, cell-cell interaction analysis revealed increased communications between mesangium and other cell types, uncovering how morbidity inside glomerulus spreads to whole kidney, which results in the genetic changes of kidney resident immune cells. Prominent interaction decreasing in intercalated cells leads to the discovery of a transitional cell type, which exhibited significant EMT and fibrosis features. Our work comprehensively characterized the pathological mesangial signatures, highlighting the step-by-step pathogenic process of IgA nephropathy from mesangium to epithelium.
Data Accessibility:   
Controlled access Request Data
BioProject:
Study type:
Disease Study
Disease name:
IgA glomerulonephritis
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
DAC name:
BIOPIC_TangLab
Contact person:
Tang Fuchou
Email:
tangfuchou@pku.edu.cn
Description:
Laboratory of Stem Cells and Epigenetics
Individuals & samples
Individual Accession
Individual Name
Gender
Sample Accession
Sample Name
Sample Description
Individual Accession
Individual Name
Gender
Sample Accession
Sample Name
Sample Description
HRI067349IgAN_01maleHRS092055IgAN_01_001polyA RNA
HRI067349IgAN_01maleHRS092056IgAN_01_002polyA RNA
HRI067349IgAN_01maleHRS092057IgAN_01_003polyA RNA
HRI067349IgAN_01maleHRS092058IgAN_01_004polyA RNA
HRI067349IgAN_01maleHRS092059IgAN_01_005polyA RNA
HRI067349IgAN_01maleHRS092060IgAN_01_006polyA RNA
HRI067349IgAN_01maleHRS092061IgAN_01_007polyA RNA
HRI067349IgAN_01maleHRS092062IgAN_01_008polyA RNA
HRI067349IgAN_01maleHRS092063IgAN_01_009polyA RNA
HRI067349IgAN_01maleHRS092064IgAN_01_010polyA RNA
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Run accession
Files
Experiment
Experiment title
Platform
Sample
Run accession
Files
Experiment
Experiment title
Platform
Sample
HRR128141HRR128141_f1.fq.gz (0.18 GB)HRX106848IgAN_01_001Illumina HiSeq 4000HRS092055 (SAMC1462542)
HRR128141HRR128141_r2.fq.gz (0.17 GB)HRX106848IgAN_01_001Illumina HiSeq 4000HRS092055 (SAMC1462542)
HRR128142HRR128142_f1.fq.gz (0.21 GB)HRX106849IgAN_01_002Illumina HiSeq 4000HRS092056 (SAMC1462546)
HRR128142HRR128142_r2.fq.gz (0.18 GB)HRX106849IgAN_01_002Illumina HiSeq 4000HRS092056 (SAMC1462546)
HRR128143HRR128143_f1.fq.gz (0.24 GB)HRX106850IgAN_01_003Illumina HiSeq 4000HRS092057 (SAMC1462549)
HRR128143HRR128143_r2.fq.gz (0.20 GB)HRX106850IgAN_01_003Illumina HiSeq 4000HRS092057 (SAMC1462549)
HRR128144HRR128144_f1.fq.gz (0.01 GB)HRX106851IgAN_01_004Illumina HiSeq 4000HRS092058 (SAMC1462553)
HRR128144HRR128144_r2.fq.gz (0.01 GB)HRX106851IgAN_01_004Illumina HiSeq 4000HRS092058 (SAMC1462553)
HRR128145HRR128145_f1.fq.gz (0.02 GB)HRX106852IgAN_01_005Illumina HiSeq 4000HRS092059 (SAMC1462557)
HRR128145HRR128145_r2.fq.gz (0.01 GB)HRX106852IgAN_01_005Illumina HiSeq 4000HRS092059 (SAMC1462557)
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Submitter:   Tang Fuchou / tangfuchou@pku.edu.cn
Organization:   Peking University
Submission date:   2020-09-21
Requests:   44