NGDC - GSA for Human

HRA000342

HRA000342.xlsx

Title:

Single-Cell Transcriptomics reveals novel immune mechanisms of the onset and progression of IgA nephropathy

Release date:

2021-01-20

Description:

IgA nephropathy represents the most prevalent chronic nephrosis worldwide. However, pathogenesis about IgA deposition and end-stage renal failure is still not well defined. Using single-cell RNA-seq, we identified the mesangial membrane receptor for IgA, which collaborates with increased extracellular matrix proteins and protease inhibitor to facilitate IgA deposition. Meanwhile, cell-cell interaction analysis revealed increased communications between mesangium and other cell types, uncovering how morbidity inside glomerulus spreads to whole kidney, which results in the genetic changes of kidney resident immune cells. Prominent interaction decreasing in intercalated cells leads to the discovery of a transitional cell type, which exhibited significant EMT and fibrosis features. Our work comprehensively characterized the pathological mesangial signatures, highlighting the step-by-step pathogenic process of IgA nephropathy from mesangium to epithelium.

Data Accessibility:

Controlled access Request Data

BioProject:

PRJCA003506

Study type:

Disease Study

Disease name:

IgA glomerulonephritis

Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.

DAC NO.:

HDAC000073

DAC name:

BIOPIC_TangLab

Contact person:

Tang Fuchou

Email:

tangfuchou@pku.edu.cn

Description:

Laboratory of Stem Cells and Epigenetics

Aspera Command Line