| HRA000426
(Controlled Access)
|
Thoracic aortic tissue was obtained from 8 TAAD human patients undergoing thoracic aneurysm repair surgery. As a control, thoracic aortic tissue from 6 donors with cardiomyopathy undergoing cardiac transplantation was also collected. These tissue samples were subjected to bulk RNA-seq. In addition, to examine the transcriptomic characteristics of macrophages/monocytes in TAAD patients, thoracic aortic tissue and peripheral blood from four TAAD patients were collected. CD11b+ macrophages/monocytes were sorted with antibody-bound magnetic beads from tissue and PBMCs. CD11b+ cells of tissue, CD11b- cells of tissue and CD11b+ PBMCs were subjected to bulk RNA-seq. |
