样本编号 SAMC1570731
外部数据库编号 GSA-Human: HRS143704
样品名称 OF2_blood
样本标题 OF2_blood
样品类型 Human sample
物种名称 Homo sapiens
描述信息 old female
样本属性 *该样本包含更多受控访问信息,请通过GSA-Human系统申请项目HRA000624数据获取。
发布日期 2021-08-06
项目编号 PRJCA003693
提交者 Wenru  Su  (suwr3@mail.sysu.edu.cn)
提交单位 Zhongshan Ophthalmic Center,Sun Yat-sen University
提交日期 2023-06-18

样本包含数据信息

资源名称 描述
GSA-Human (1) -
HRA000624  (Controlled Access) Difference in immune function roots from multiple factors, among which sex and aging have greatest effect. However, the roles of sex and aging in immunity remain elusive. We profiled immunocytes obtained from males and females, young and old, at the single-cell resolution and constructed a precise atlas of blood circulating immunocytes. young females showed stronger T and B cell-mediated immunity and defense response. Aging increased the sex-related differences in immunocytes, with respect to the cellular composition and inflammatory signaling. Males showed higher accumulation of inflammation during aging. Moreover, cell-cell communication presented different trends concerning female and male aging. These findings provide a rich resource for further validation and expansion of molecular understanding of sex-biased disease susceptibility across life span
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