样本编号	SAMC1665160
外部数据库编号	GSA-Human: HRS166191
样品名称	NR140912_5
样本标题	Cancer tissue
样品类型	Human sample
物种名称	Homo sapiens
描述信息	In this study, we investigated the availability and function of extrachromosomal DNA in the gastric cardia adenocarcinoma (GCA) from a Chinese cohort of gastric cardia adenocarcinoma with whole-genome sequencing (WGS), whole-exome sequencing (WES), and immunohistochemistry. For the first time, we identified the ecDNA amplicons present in most GCA patients, and found that some oncogenes are present as ecDNA amplicons in these patients.
样本属性	*该样本包含更多受控访问信息，请通过GSA-Human系统申请项目HRA000814数据获取。
发布日期	2021-10-21
项目编号	PRJCA004901
提交者	Xue Ke Zhao (ldwang2007@126.com)
提交单位	Zhengzhou University
提交日期	2023-06-18

样本包含数据信息

资源名称	描述
GSA-Human (1)	-
HRA000814 (Controlled Access)	In this study, we investigated the availability and function of extrachromosomal DNA in the gastric cardia adenocarcinoma (GCA) from a Chinese cohort of gastric cardia adenocarcinoma with whole-genome sequencing (WGS), whole-exome sequencing (WES), and immunohistochemistry. For the first time, we identified the ecDNA amplicons present in most GCA patients, and found that some oncogenes are present as ecDNA amplicons in these patients. These oncogene ecDNA amplicons are associated with the chromothripsis process. Strikingly, we found that two oncogenes amplicons have a diverse correlation with patients prognosis. The diverse association of ecDNA amplicons and patient prognosis may help us to design personal therapy strategies for these GCA patients.

资源名称

描述

GSA-Human (1)

HRA000814 (Controlled Access)

In this study, we investigated the availability and function of extrachromosomal DNA in the gastric cardia adenocarcinoma (GCA) from a Chinese cohort of gastric cardia adenocarcinoma with whole-genome sequencing (WGS), whole-exome sequencing (WES), and immunohistochemistry. For the first time, we identified the ecDNA amplicons present in most GCA patients, and found that some oncogenes are present as ecDNA amplicons in these patients. These oncogene ecDNA amplicons are associated with the chromothripsis process. Strikingly, we found that two oncogenes amplicons have a diverse correlation with patients prognosis. The diverse association of ecDNA amplicons and patient prognosis may help us to design personal therapy strategies for these GCA patients.