e.g., HRA000087; HRA000150
HRA001033
Title:
Single-cell RNA-seq and bulk RNA data of non-small cell lung cancer during neoadjuvant immunotherapy
Release date:
2023-01-28
Description:
Most patients are still refractory to immunotherapy or acquire resistance. We characterized the single-cell transcriptomes of ~92000 cells from 15 non-small cell lung cancer (NSCLC) before and after neoadjuvant PD-1 blockade combined with chemotherapy to decode immunotherapy resistance mechanisms. In addition, we also performed bulk RNA-seq from another 24 patients before therapy as a validation cohort. Our study offers invaluable resources for uncovering immunotherapy resistance.
Data Accessibility:   
Controlled access Request Data
BioProject:
Study type:
Disease Study
Disease name:
non-small cell lung carcinoma
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
DAC name:
transcriptomic for NSCLC
Contact person:
Zhang Peng
Email:
zhangpeng1121@tongji.edu.cn
Description:
We single-cell RNA-seq from 15 non-small cell lung cancer (NSCLC) before and after neoadjuvant PD-1 blockade combined with chemotherapy to decode immunotherapy resistance mechanisms. In addition, we also performed bulk RNA-seq from another 24 patients before therapy as a validation cohort.
Individuals & samples
Individual Accession
Individual Name
Gender
Sample Accession
Sample Name
Sample Description
Individual Accession
Individual Name
Gender
Sample Accession
Sample Name
Sample Description
HRI134146Patient1maleHRS261231BD-immune-1BD Biosciences single-cell RNA sequencing of NSCLC before neoadjuvant immunotherapy
HRI134147Patient2femaleHRS261232BD-immune-2BD Biosciences single-cell RNA sequencing of NSCLC after neoadjuvant immunotherapy
HRI134148Patient3maleHRS261233BD-immune-3BD Biosciences single-cell RNA sequencing of NSCLC after neoadjuvant immunotherapy
HRI134149Patient4maleHRS261234BD-immune-4BD Biosciences single-cell RNA sequencing of NSCLC after neoadjuvant immunotherapy
HRI134150Patient5femaleHRS261235BD-immune-5BD Biosciences single-cell RNA sequencing of NSCLC before neoadjuvant immunotherapy
HRI134150Patient5femaleHRS261246MM-RNA-1Bulk RNA sequencing of NSCLC before neoadjuvant immunotherapy
HRI134151Patient6femaleHRS261236BD-immune-6BD Biosciences single-cell RNA sequencing of NSCLC after neoadjuvant immunotherapy
HRI134152Patient7maleHRS261237BD-immune-7BD Biosciences single-cell RNA sequencing of NSCLC after neoadjuvant immunotherapy
HRI134152Patient7maleHRS261247MM-RNA-2Bulk RNA sequencing of NSCLC before neoadjuvant immunotherapy
HRI134153Patient8femaleHRS261238BD-immune-8BD Biosciences single-cell RNA sequencing of NSCLC before neoadjuvant immunotherapy
Showing 1 to 10 of 39 rows rows per page
Run accession
Files
Experiment
Experiment title
Platform
Sample
Run accession
Files
Experiment
Experiment title
Platform
Sample
HRR330421HRR330421_f1.fastq.gz (22.72 GB)HRX283730NSCLC1-immune-scRNAIllumina NovaSeq 6000HRS261231 (SAMC1839885)
HRR330421HRR330421_r2.fastq.gz (24.42 GB)HRX283730NSCLC1-immune-scRNAIllumina NovaSeq 6000HRS261231 (SAMC1839885)
HRR330422HRR330422_f1.fastq.gz (26.26 GB)HRX283731NSCLC2-immune-scRNAIllumina NovaSeq 6000HRS261232 (SAMC1839889)
HRR330422HRR330422_r2.fastq.gz (27.28 GB)HRX283731NSCLC2-immune-scRNAIllumina NovaSeq 6000HRS261232 (SAMC1839889)
HRR330423HRR330423_f1.fastq.gz (23.59 GB)HRX283732NSCLC3-immune-scRNAIllumina NovaSeq 6000HRS261233 (SAMC1839894)
HRR330423HRR330423_r2.fastq.gz (25.65 GB)HRX283732NSCLC3-immune-scRNAIllumina NovaSeq 6000HRS261233 (SAMC1839894)
HRR330424HRR330424_f1.fastq.gz (20.74 GB)HRX283733NSCLC4-immune-scRNAIllumina NovaSeq 6000HRS261234 (SAMC1839898)
HRR330424HRR330424_r2.fastq.gz (22.23 GB)HRX283733NSCLC4-immune-scRNAIllumina NovaSeq 6000HRS261234 (SAMC1839898)
HRR330425HRR330425_f1.fastq.gz (22.90 GB)HRX283734NSCLC5-immune-scRNAIllumina NovaSeq 6000HRS261235 (SAMC1839902)
HRR330425HRR330425_r2.fastq.gz (24.24 GB)HRX283734NSCLC5-immune-scRNAIllumina NovaSeq 6000HRS261235 (SAMC1839902)
Showing 1 to 10 of 78 rows rows per page
Submitter:   Zhang Peng / zhangpeng1121@tongji.edu.cn
Organization:   Shanghai Pulmonary Hospital Tongji University
Submission date:   2021-07-06
Requests:   43