| HRA002591
(Controlled Access)
|
Fumarate Hydratase Deficient Renal Cell Carcinoma (FH-RCC), characterized as carrying pathogenic germline or somatic FH alteration, is a rare subtype of renal cell carcinoma manifested with high invasive and early metastatic potential. However, the distinct multi-omics features and evolutionary relationships between metastatic and primary lesions are still unclear. In this study, whole-exome, RNA and DNA-methylation sequencing were performed for primary-metastatic paired specimens from 19 FH-RCC cases. |
