样本编号 SAMC3051241
外部数据库编号 GSA-Human: HRS916959
样品名称 H2_blood
样本标题 H2_blood
样品类型 Human sample
物种名称 Homo sapiens
描述信息 blood
样本属性 *该样本包含更多受控访问信息,请通过GSA-Human系统申请项目HRA005286数据获取。
发布日期 2023-09-06
项目编号 PRJCA015964
提交者 Chen  Wu  (chenwu@cicams.ac.cn)
提交单位 Cancer Hospital, Chinese Academy of Medical Sciences
提交日期 2023-09-07

样本包含数据信息

资源名称 描述
GSA-Human (1) -
HRA005286  (Controlled Access) We conducted whole-genome and whole-exome sequencing of LCM-dissected micro-biopsies from 4 esophageal squamous cell carcinoma (ESCC) patients, 10 individuals with pre-cancer intraepithelial neoplasia, and 14 individuals without cancer or pre-cancer pathology from a ESCC high-risk region in China. For each sample, multiple adjacent normal and neoplasia micro-biopsies were collected and sequenced, enabling us to reconstruct the phylogeny and reveal the dynamic mutational landscape during the cancer development. Our results delineated a clear evolutionary path from clones in normal aging esophagus to ESCC.
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