ChickenGTEx

As an essential part of the ongoing Farm animal Genotype-Tissue Expression (FarmGTEx) project, the ChickenGTEx aims to build a comprehensive public catalogue of genetic regulatory variants associated with multiple types of transcriptomic phenotypes in distinct biological contexts (e.g., tissues, cell types, development periods, gender, environmental exposures, and genetic backgrounds) in chickens. This resource will serve as a valuable reference for fundamental biology (e.g., genetic regulations related to development, immune response, and tissue/cell type specificity), bird or vertebrate evolution, comparative transcriptomes, applied genetics (e.g., chicken precision breeding, and food security), and human biomedicine.

Exploring the ChickenGTEx atlas by variants, genes, and tissues

Publications

An atlas of regulatory elements in chicken: A resource for chicken genetics and genomics.
Science Advance. 9, eade1204 (2023). DOI:10.1126/sciadv.ade1204
The CattleGTEx atlas reveals regulatory mechanisms underlying complex traits
Nature Genetics, 54, 1273-1274 (2022), DOI: 10.1038/s41588-022-01155-3
Comparative transcriptome in large-scale human and cattle populations
Genome Biology, 23, 176 (2022), DOI: 10.1186/s13059-022-02745-4
A multi-tissue atlas of regulatory variants in cattle
Nature Genetics, 54, 1438–1447 (2022), DOI: 10.1038/s41588-022-01153-5
The conservation of human functional variants and their effects across livestock species
Communications Biology, 5, 1003 (2022), DOI: 10.1038/s42003-022-03961-1
Pig genome functional annotation enhances the biological interpretation of complex traits and human disease
Nature Communications, 12, 5848 (2021), DOI: 10.1038/s41467-021-26153-7
A compendium of genetic regulatory effects across pig tissues.
bioRxiv, 2022, DOI: 10.1101/2022.11.11.516073
Genetic score omics regression and multi-trait meta-analysis detect widespread cis -regulatory effects shaping bovine complex traits
bioRxiv, 2022, DOI: 10.1101/2022.07.13.499886
Gene expression and RNA splicing explain large proportions of the heritability for complex traits in cattle
bioRxiv, 2022, DOI: 10.1101/2022.05.30.494093
Building an atlas of transposable elements reveals the extensive roles of young SINE in gene regulation, genetic diversity, and complex traits in pigs
bioRxiv, 2022, DOI: 10.1101/2022.02.07.479475
Copyright © the FarmGTEx-ChickenGTEx Consortium.
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