Disease - EDK - BIG Data Center

Disease name	Atherosclerosis
Classfication	Cardiovascular system disease
Related Enzyme(s)
EFO	EFO:0003914
DOID	1936
OMIM	-
NCI	NCI:C35768
Definition	Atherosclerosis is a disease in which the inside of an artery narrows due to the build of plaque. Initially there are generally no symptoms. When severe it can result in coronary artery disease, stroke, peripheral artery disease, or kidney problems depending on the arteries which are affected. Symptoms, if they occur, generally do not begin until middle age.

Gene symbol	Species	Enzyme	Editing site(s)	Editing Type	PMID	RADAR	REDIportal	Description
CTSS	Human	ADAR1	41	A-to-I	27595325			RNA-editing in the CTSS 3'UTR will knockdown the CTSS mRNA expression, and RNA-editing of CTSS mRNA also regulate the RNA-binding protein HuR, deficiency of cathepsin S reduces atherosclerosis and angiogenesis in vivo. And it will reduce the binding efficiency of HuR, which will lead to Decrease the stability of CTSS mRNA.

Gene symbol	Disease	Enzyme	Editing Sites	Editing Type	miRBase	PMID	Description
hsa-mir-27b	Atherosclerosis	-	1	A-to-I	MI0000440	29527417	pri-mir-27b editing in aortic wall and internal mammary artery are associated with increased plasma levels of high-density lipoprotein
hsa-miR-605	Atherosclerosis	-	1	A-to-I	MI0003618	29527417	mir-605 editing in the aortic wall and internal mammary artery are associated with increased plasma levels of high-density lipoprotein.