It provides genetic and phenotypic information from thousands of trios/duos families recruited by the [BIGCS Project](http://www.bigcs.com.cn/) in Guangzhou, China. The Phase I study includes 332 trios (father-mother-offspring), 1,406 duos (14 father-offspring and 1,392 mother-offspring) and 245 single individuals (70 children, 150 adult females and 25 adult males), for a total of 4,053 individual samples. Each of the samples was whole genome sequenced to 4-7x. This dataset delivers periodical and useful genetic variation information and scientific insights derived from the analysis of the sequencing data. The results aim to promote genetic research and precision medicine actions in China. The delivering information includes the detected variants and the corresponding allele frequency, functional annotation, and frequency comparison to the global populations, etc.