Single cell dissection of bronchoalveolar immune cells in patients with checkpoint inhibitor-related pneumonitis
| Title | Single cell dissection of bronchoalveolar immune cells in patients with checkpoint inhibitor-related pneumonitis |
|---|---|
| Description | Immune checkpoint inhibitors (ICIs) therapy induced pneumonitis (CIP) complicates this effective therapy in patients with non-small cell lung cancer (NSCLC) and makes it difficult to classify from other pneumonitis. Comprehensively dissecting the key cellular players and molecular pathways associated with CIP pathobiology is critical for precision diagnosis and develop novel therapy strategy of CIP. Here, we implemented comprehensive single-cell transcriptome, flow cytometry and cytokine expression analysis to shed light on the complexity of the immunological responses in the bronchoalveolar microenvironment from NSCLC patients with CIP. |
| Organism | Homo |
| Data Type | Transcriptomic |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA008590 |
| Release Date | 2022-12-31 |
| Submitter | Yi Hu (huyi_0912@126.com) |
| Organization | the Fifth Medical Center of PLA General Hospital |
| Submission Date | 2022-03-09 |
The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX001006-20-01 | BP6.count.tar.gz | 1 | Transcriptomic | 14.55 MB | tar | 0 | Unavailable |
| OMIX001006-20-02 | BP2.count.tar.gz | 1 | Transcriptomic | 11.54 MB | tar | 0 | Unavailable |
| OMIX001006-20-03 | BC3.count.tar.gz | 1 | Transcriptomic | 19.37 MB | tar | 0 | Unavailable |
| OMIX001006-20-04 | BP3.count.tar.gz | 1 | Transcriptomic | 37.77 MB | tar | 0 | Unavailable |
| OMIX001006-20-05 | BC1.count.tar.gz | 1 | Transcriptomic | 18.27 MB | tar | 0 | Unavailable |
| OMIX001006-20-06 | BP1.count.tar.gz | 1 | Transcriptomic | 3.93 MB | tar | 0 | Unavailable |
| OMIX001006-20-07 | BC2.count.tar.gz | 1 | Transcriptomic | 16.76 MB | tar | 0 | Unavailable |
| OMIX001006-20-08 | BP5.count.tar.gz | 1 | Transcriptomic | 8.74 MB | tar | 0 | Unavailable |
| OMIX001006-20-09 | BP4.count.tar.gz | 1 | Transcriptomic | 13.79 MB | tar | 0 | Unavailable |