| Title | Single-cell RNA-sequencing reveals tumor heterogeneity in adamantinomatous craniopharyngiomas |
|---|---|
| Description | Adamantinomatous craniopharyngioma (ACP) is a rare brain tumor that occurs in the sellar region. The specific location and aggressive growth pattern of ACP result in a poor prognosis. However, the cellular composition of ACP and the molecular mechanisms involved in ACP tumorigenesis and progression remain unclear. This study aims to comprehensively characterize the tumor heterogeneity landscape and tumor microenvironment of ACP based on single-cell RNA-sequencing (scRNA-seq) and provide a basis for the improvement of clinical treatment strategies. |
| Organism | Homo sapiens |
| Data Type | Mixed |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA008838 |
| Release Date | 2022-04-12 |
| Submitter | Jianguo Xu (xujg@scu.edu.cn) |
| Organization | West China Hospital Sichuan University |
| Submission Date | 2022-03-25 |
HTTP download speed may be slow. It is highly recommended that you download the dataset using a dedicated FTP tool (such as FileZilla Client).
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX001061-20-01 | ACP1-matrix | 1 | Transcriptomic | 463.09 MB | tar | Controlled |
| OMIX001061-20-02 | ACP2-matrix | 1 | Transcriptomic | 192.33 MB | tar | Controlled |
| OMIX001061-20-03 | ACP3-matrix | 1 | Transcriptomic | 453.1 MB | tar | Controlled |
| OMIX001061-20-04 | ACP2-features | 1 | Transcriptomic | 1.32 MB | tar | Controlled |
| OMIX001061-20-05 | ACP1-barcodes | 1 | Transcriptomic | 258.5 KB | tar | Controlled |
| OMIX001061-20-06 | ACP3-features | 1 | Transcriptomic | 1.32 MB | tar | Controlled |
| OMIX001061-20-07 | ACP3-barcodes | 1 | Transcriptomic | 256.5 KB | tar | Controlled |
| OMIX001061-20-08 | ACP2-barcodes | 1 | Transcriptomic | 110.5 KB | tar | Controlled |
| OMIX001061-20-09 | ACP1-features | 1 | Transcriptomic | 1.32 MB | tar | Controlled |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery | Advanced Science | 2025-11 | OMIX001061 | Deposit |
| Single-cell RNA sequencing highlights intratumor heterogeneity and intercellular network featured in adamantinomatous craniopharyngioma | Science Advances | 2023-04 | OMIX001061 | Deposit |