OMIX001073

1Summary
Title Single cell analysis coupled with TCR sequencing of gastric tumor reveals complex intercellular interaction and an alternative T cell exhaustion trajectory
Description TCR information, BCR information and processed expression matrix from single-cell RNA sequencing.
Organism Homo sapiens
Data Type Expression Profiling
Data Accessibility Open-access
BioProject PRJCA004201
Release Date 2022-08-29
Submitter Xun Lan (xlan@tsinghua.edu.cn)
Organization Tsinghua University
Submission Date 2022-04-07
2Files & Download

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File ID File Title Number/Samples File Type File Size File Suffix Download
OMIX001073-20-01 B_cell_matrix 3 Expression Profiling 92.89 MB zip
OMIX001073-20-02 B_cell_annotations 1 Expression Profiling 2.32 MB tsv
OMIX001073-20-03 All_cell_matrix 3 Expression Profiling 1.05 GB zip
OMIX001073-20-04 All_cell_annotations 1 Expression Profiling 19.52 MB tsv
OMIX001073-20-06 Epithelial_cell_matrix 3 Expression Profiling 147.81 MB zip
OMIX001073-20-07 T_cell_matrix 3 Expression Profiling 279.44 MB zip
OMIX001073-20-09 NK_cell_annotations 1 Expression Profiling 2.07 MB tsv
OMIX001073-20-10 NK_cell_matrix 3 Expression Profiling 81.06 MB zip
OMIX001073-20-11 Stroma_cell_annotations 1 Expression Profiling 803.55 KB tsv
OMIX001073-20-12 Stroma_cell_matrix 3 Expression Profiling 44.32 MB zip
OMIX001073-20-13 Bulk_normalized_expression 1 Expression Profiling 9.9 MB csv
OMIX001073-20-14 Myeloid_cell_matrix 3 Expression Profiling 37.73 MB zip
OMIX001073-20-15 Myeloid_cell_annotations 1 Expression Profiling 497.91 KB tsv
OMIX001073-16 Epithelial_cell_annotations 1 Expression Profiling 3.7 MB tsv
OMIX001073-17 T_cell_annotations 1 Expression Profiling 14.35 MB tsv
3Relevant Publications
Paper Title Journal Name Publish Time Accession Citing Type
Immunotyping the Tumor Microenvironment Reveals Molecular Heterogeneity for Personalized Immunotherapy in Cancer Advanced Science 2025-05 OMIX001073 Secondary use
Hypoxia‐based critical gene biomarkers as prognostic reporters for gastric adenocarcinoma Environmental Toxicology 2023-12 OMIX001073 Secondary use
FAP upregulates PD-L1 expression in cancer-associated fibroblasts to exacerbate T cells dysfunction and suppress anti-tumor immunity Cancer Letters 2025-01 OMIX001073 Secondary use
Multi-omics analysis reveals the heterogeneity and interactions among stromal and tumor cells in gastric cancer Translational Oncology 2026-01 OMIX001073 Secondary use
scRNA-seq of gastric tumor shows complex intercellular interaction with an alternative T cell exhaustion trajectory Nature Communications 2022-08 OMIX001073 Deposit
Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors Nature Communications 2025-05 OMIX001073 Secondary use
Nociceptive neurons promote gastric tumour progression via a CGRP–RAMP1 axis Nature 2025-02 OMIX001073 Secondary use
Multi-omics analysis identifies diagnostic circulating biomarkers and potential therapeutic targets, revealing IQGAP1 as an oncogene in gastric cancer npj Precision Oncology 2025-04 OMIX001073 Secondary use
Nociceptive neurons interact directly with gastric cancer cells via a CGRP/Ramp1 axis to promote tumor progression bioRxiv 2024-03 OMIX001073 Secondary use
Sketching T cell atlases in the single‐cell era: challenges and recommendations Immunology and Cell Biology 2025-06 OMIX001073 Secondary use
Loss of ADAR1 in macrophages in combination with interferon gamma suppresses tumor growth by remodeling the tumor microenvironment Journal for Immunotherapy of Cancer 2023-11 OMIX001073 Secondary use
Blood TCTP as a potential biomarker associated with immunosuppressive features and poor clinical outcomes in metastatic gastric cancer Journal for Immunotherapy of Cancer 2025-03 OMIX001073 Secondary use
Mutual exclusivity and co-occurrence patterns of immune checkpoints indicate NKG2A relates to anti-PD-1 resistance in gastric cancer Journal of Translational Medicine 2024-08 OMIX001073 Secondary use
Re-analysis of single cell and spatial transcriptomics data reveals B cell landscape in gastric cancer microenvironment and its potential crosstalk with tumor cells for clinical prognosis Journal of Translational Medicine 2024-08 OMIX001073 Secondary use
C3+ cancer-associated fibroblasts promote tumor growth and therapeutic resistance in gastric cancer via activation of the NF-κB signaling pathway Journal of Translational Medicine 2024-12 OMIX001073 Secondary use
ESRP1 exerts anti-tumor role by promoting ferroptosis in diffuse-type gastric cancer Journal of Experimental & Clinical Cancer Research 2025-06 OMIX001073 Secondary use
Integrative analysis of single-cell and bulk RNA sequencing reveals the oncogenic role of ANXA5 in gastric cancer and its association with drug resistance Frontiers in Immunology 2025-03 OMIX001073 Secondary use
Transcriptional profiling reveals H.pylori -associated genes induced inflammatory cell infiltration and chemoresistance in gastric cancer Frontiers in Immunology 2025-05 OMIX001073 Secondary use

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