OMIX001122

1Summary
Title Single-cell RNA profiling and spatial transcriptomics of primary biliary cholangitis
Description Primary biliary cholangitis is an autoimmune liver disease characterized by selective destructions of small- and medium-sized intrahepatic bile ducts. However, the reasons why PBC selectively targets these bile ducts and its underlying mechanisms are still largely unclear. In this study, liver samples from control and PBC patients were used for single-cell RNA sequencing and spatial transcriptomics to explore the pathogenesis of this disease.
Organism Homo sapiens
Data Type Other Type of Genomic Data
Data Accessibility Controlled-access
BioProject PRJCA009122
Release Date 2023-02-09
Submitter Xi Li (lixi1988xn@163.com)
Organization Southwest Hospital of AMU
Submission Date 2022-05-10
2Files & Download

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File ID File Title Number/Samples File Type File Size File Suffix Download
OMIX001122-99-01 processed_data_Spatial_transcriptomics 6 Other Type of Genomic Data 34.63 MB rar Controlled
OMIX001122-99-02 processed_data_5_scRNA_seq 27 Other Type of Genomic Data 446.95 MB rar Controlled
OMIX001122-99-03 processed_data_3_scRNA_seq 27 Other Type of Genomic Data 1023.77 MB rar Controlled
3Relevant Publications
Paper Title Journal Name Publish Time Accession Citing Type
Unique DUOX2+ACE2+ small cholangiocytes are pathogenic targets for primary biliary cholangitis Nature Communications 2023-02 OMIX001122 OMIX001127 Deposit

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