GCTOF-MS Combined LC-QTRAP-MS/MS Reveals Metabolic Difference Between Osteoarthritis and Osteoporotic Osteoarthritis and the Intervention Effect of Erxian Decoction
Title | GCTOF-MS Combined LC-QTRAP-MS/MS Reveals Metabolic Difference Between Osteoarthritis and Osteoporotic Osteoarthritis and the Intervention Effect of Erxian Decoction |
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Description | The purpose of this study was to analyze the effect of OP on OA metabolites by using metabolomic methods and to explore the intervention mechanism of EXD on osteoporotic OA.Thirty-two SD rats were randomly divided into normal group, OA group, OP-OA group, and EXD group. EXD was administered by gavage. Histopathological evaluation of cartilage tissue was performed using Saffron fast green and HE staining. Western blot and qRT-PCR were used to detect the expression levels of chondrogenesis genes SOX9, COL2A1, and COMP in cartilage tissue. GC-TOFMS and LC-QTRAP-MS/MS metabolomics methods were used to analyze the changes of metabolites in serum samples of rats in each group. |
Organism | Rattus |
Data Type | Other Type of Metabolome Data |
Data Accessibility | Open-access |
BioProject | PRJCA010637 |
Release Date | 2022-07-22 |
Submitter | Zhenyuan Ma (906459075@qq.com) |
Organization | Affiliated Hospital of Nanjing University of Chinese Medicine |
Submission Date | 2022-07-20 |
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File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
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OMIX001328-01 | data.tar | 1 | Other Type of Metabolome Data | 6.24 GB | tar.gz | 0 | |
OMIX001328-02 | medicine.tar | 1 | Other Type of Metabolome Data | 1.34 GB | tar.gz | 0 | |
OMIX001328-03 | original data 2.tar | 1 | Other Type of Metabolome Data | 18.29 MB | tar.gz | 0 |