OMIX

GCTOF-MS Combined LC-QTRAP-MS/MS Reveals Metabolic Difference Between Osteoarthritis and Osteoporotic Osteoarthritis and the Intervention Effect of Erxian Decoction

OMIX001328

1Summary
Title GCTOF-MS Combined LC-QTRAP-MS/MS Reveals Metabolic Difference Between Osteoarthritis and Osteoporotic Osteoarthritis and the Intervention Effect of Erxian Decoction
Description The purpose of this study was to analyze the effect of OP on OA metabolites by using metabolomic methods and to explore the intervention mechanism of EXD on osteoporotic OA.Thirty-two SD rats were randomly divided into normal group, OA group, OP-OA group, and EXD group. EXD was administered by gavage. Histopathological evaluation of cartilage tissue was performed using Saffron fast green and HE staining. Western blot and qRT-PCR were used to detect the expression levels of chondrogenesis genes SOX9, COL2A1, and COMP in cartilage tissue. GC-TOFMS and LC-QTRAP-MS/MS metabolomics methods were used to analyze the changes of metabolites in serum samples of rats in each group.
Organism Rattus
Data Type Other Type of Metabolome Data
Data Accessibility Open-access
BioProject PRJCA010637
Release Date 2022-07-22
Submitter Zhenyuan Ma (906459075@qq.com)
Organization Affiliated Hospital of Nanjing University of Chinese Medicine
Submission Date 2022-07-20
2Files & Download

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File ID File Title Number/Samples File Type File Size File Suffix Download Times Download
OMIX001328-01 data.tar 1 Other Type of Metabolome Data 6.24 GB tar.gz 0
OMIX001328-02 medicine.tar 1 Other Type of Metabolome Data 1.34 GB tar.gz 0
OMIX001328-03 original data 2.tar 1 Other Type of Metabolome Data 18.29 MB tar.gz 0

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