OMIX

Shanghai General Hospital Osteosarcoma Cohort

OMIX002042

1Summary
Title Shanghai General Hospital Osteosarcoma Cohort
Description Osteosarcoma (OS) is the primary malignant bone tumor that most commonly affects children, adolescents, and young adults. Here we present the first large cohort of 121 OS patients from Shanghai General Hospital (SGH-OS Cohort), using hybrid-capture DNA sequencing, array-based DNA copy number, DNA methylation profiling and mRNA sequencing. Through integrating multi-omics data, we obtained a comprehensive genomic, epigenomic and transcriptomic landscape of OS and uncovered four distinct molecular subtypes with varied oncogenic factors. Moreover, we explored the diversity of clinical outcomes and the subtype-based targeted intervention that may influence OS clinical management. Our study provides a valuable insight into the biology of this disease, and a strong foundation of future precision medicine for each subtype that will eventually improve overall survival of osteosarcoma.
Organism Homo sapiens
Data Type Methylation profiling by Array
Data Accessibility Controlled-access
BioProject PRJCA012376
Release Date 2022-11-01
Submitter Yingqi Hua (yhua@shsmu.edu.cn)
Organization Shanghai bone tumor Institute, Shanghai General hospital, Shanghai Jiaotong University School of Medicine
Submission Date 2022-10-12
2Files & Download

The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.

File ID File Title Number/Samples File Type File Size File Suffix Download Times Download
OMIX002042-01 rawdata.wjz.116s.zip 232 Methylation profiling by Array 1.58 GB wjz.116s.zip 0 Unavailable

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