| Title | Shanghai General Hospital Osteosarcoma Cohort |
|---|---|
| Description | Osteosarcoma (OS) is the primary malignant bone tumor that most commonly affects children, adolescents, and young adults. Here we present the first large cohort of 121 OS patients from Shanghai General Hospital (SGH-OS Cohort), using hybrid-capture DNA sequencing, array-based DNA copy number, DNA methylation profiling and mRNA sequencing. Through integrating multi-omics data, we obtained a comprehensive genomic, epigenomic and transcriptomic landscape of OS and uncovered four distinct molecular subtypes with varied oncogenic factors. Moreover, we explored the diversity of clinical outcomes and the subtype-based targeted intervention that may influence OS clinical management. Our study provides a valuable insight into the biology of this disease, and a strong foundation of future precision medicine for each subtype that will eventually improve overall survival of osteosarcoma. |
| Organism | Homo sapiens |
| Data Type | Methylation profiling by Array |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA012376 |
| Release Date | 2024-07-02 |
| Submitter | Yingqi Hua (yhua@shsmu.edu.cn) |
| Organization | Shanghai bone tumor Institute, Shanghai General hospital, Shanghai Jiaotong University School of Medicine |
| Submission Date | 2022-10-12 |
HTTP download speed may be slow. It is highly recommended that you download the dataset using a dedicated FTP tool (such as FileZilla Client).
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX002042-01 | rawdata.wjz.116s.zip | 232 | Methylation profiling by Array | 1.58 GB | zip | Controlled |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Methionine intervention induces PD-L1 expression to enhance the immune checkpoint therapy response in MTAP-deleted osteosarcoma | Cell Reports Medicine | 2025-02 | OMIX002042 | Deposit |
| Multi-omics analysis identifies osteosarcoma subtypes with distinct prognosis indicating stratified treatment | Nature Communications | 2022-10 | OMIX002042 | Deposit |
| XGBoost-Based Prediction Model of High-Risk Osteosarcoma | JCO Precision Oncology | 2025-03 | OMIX002042 | Secondary use |