Untargeted metabolomics of sera from patients with lung cancer induced cachexia
| Title | Untargeted metabolomics of sera from patients with lung cancer induced cachexia |
|---|---|
| Description | Cancer cachexia is a multifactorial syndrome featured by a rapid reduction of body weight and accounts for 20-40% of cancer-related death. However, its underlying mechanism is poorly understood. We performed untargeted metabolomics analysis of serum samples from 4 cachectic and 4 non-cachectic patients with lung adenocarcinoma to investigate the cachexia related metabolic change. Untargeted LC-MS profiling of polar metabolites was performed on a UPLC (Waters Corp, ACQUITY I-Class) coupled with tandem ESI-QTOF mass spectrometry (Waters Corp, Synapt G2-Si). The acquired MS data pretreatment were performed using the Progenesis QI software (Waters Corp. USA). The online HMDB database was used to align the molecular mass data (m/z) and label the possible metabolite of each peak. This work identified differential metabolites in sera form cachectic patients and expands the understanding of metabolic alterations associated with lung adenocarcinoma induced cachexia. |
| Organism | Homo sapiens |
| Data Type | Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA013670 |
| Release Date | 2024-03-18 |
| Submitter | Xinli Hu (huxxx025@pku.edu.cn) |
| Organization | Peking University |
| Submission Date | 2022-12-05 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX002511-01 | human_Serum | 6 | Metabolome Data by Mass Spectrometry (MS) | 1.12 GB | rar | 0 | Controlled |