| Title | Dissection of organochlorine insecticide endosulfan-induced liver injury via single-cell RNA sequencing |
|---|---|
| Description | Environment pollutants associated liver toxicity have captured increasing attention due to the increasing liver diseases in recent years. Endosulfan (ENDO), a widely used organochlorine insecticide, exerts potential health risks for multiple organs including liver. However, the underlying mechanisms of ENDO-induced liver injury remain largely unclear. Here, single cell RNA sequencing (scRNA-seq) was employed to investigate ENDO-induced liver toxicity in mice. Overall, our results reveal key genes and cellular pathways for ENDO-induced liver toxicity at single-cell resolution, providing novel insight into understanding the liver injury associated with organochlorine insecticide such as endosulfan. |
| Organism | Mus musculus |
| Data Type | Expression Profiling |
| Data Accessibility | Open-access |
| BioProject | PRJCA017116 |
| Release Date | 2025-03-26 |
| Submitter | yunmeng bai (2856450699@qq.com) |
| Organization | Shenzhen People's Hospital |
| Submission Date | 2023-05-19 |
HTTP download speed may be slow. It is highly recommended that you download the dataset using a dedicated FTP tool (such as FileZilla Client).
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX004105-01 | CTL1 | 3 | Expression Profiling | 93.8 MB | zip | |
| OMIX004105-02 | CTL2 | 3 | Expression Profiling | 68.1 MB | zip | |
| OMIX004105-03 | CTL3 | 3 | Expression Profiling | 93.9 MB | zip | |
| OMIX004105-03 | CTL3 | 3 | Expression Profiling | 93.9 MB | zip | |
| OMIX004105-03 | CTL3 | 3 | Expression Profiling | 93.9 MB | zip | |
| OMIX004105-03 | CTL3 | 3 | Expression Profiling | 93.9 MB | zip | |
| OMIX004105-07 | ENDO1 | 3 | Expression Profiling | 110.7 MB | zip | |
| OMIX004105-08 | ENDO2 | 3 | Expression Profiling | 95.9 MB | zip | |
| OMIX004105-09 | ENDO3 | 3 | Expression Profiling | 59.3 MB | zip | |
| OMIX004105-08 | ENDO2 | 3 | Expression Profiling | 95.9 MB | zip | |
| OMIX004105-09 | ENDO3 | 3 | Expression Profiling | 59.3 MB | zip |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Single-cell transcriptomic insights into endosulfan-induced liver injury: key pathways and inflammatory responses | Liver Research | 2025-05 | OMIX004105 | Deposit |