OMIX004825

1Summary
Title Allele-specific Effects of Three-dimensional Genome Architecture in Hybrid Pigs
Description In diploid mammals, allele-specific three-dimensional (3D) genome architecture may lead to imbalanced gene expression. Through ultradeep in situ Hi-C sequencing of three representative somatic tissues (liver, skeletal muscle, and brain) from hybrid pigs generated by reciprocal crosses of phenotypically and physiologically divergent Berkshire and Tibetan pigs, we uncover extensive chromatin reorganization between homologous chromosomes across multiple scales. Haplotype-based interrogation of multi-omics data revealed the tissue-dependence of 3D chromatin conformation, suggesting that parent-of-origin-specific conformation may drive gene imprinting.
Organism Sus scrofa
Data Type Other Type of Genomic Data
Data Accessibility Open-access
BioProject PRJCA008579
Release Date 2023-08-31
Submitter Long Jin (longjin@sicau.edu.cn)
Organization Sichuan Agricultural University
Submission Date 2023-08-30
2Files & Download

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File ID File Title Number/Samples File Type File Size File Suffix Download
OMIX004825-01 Muscle_BM4_HiC 1 Other Type of Genomic Data 3.59 GB hic
OMIX004825-02 Brain_BF4_HiC 1 Other Type of Genomic Data 2.62 GB hic
OMIX004825-03 Brain_TF4_HiC 1 Other Type of Genomic Data 2.76 GB hic
OMIX004825-04 Liver_TM4_HiC 1 Other Type of Genomic Data 2.7 GB hic
OMIX004825-05 Liver_BM4_HiC 1 Other Type of Genomic Data 2.76 GB hic
OMIX004825-06 Brain_TM3_HiC 1 Other Type of Genomic Data 3.02 GB hic
OMIX004825-07 Liver_TM3_HiC 1 Other Type of Genomic Data 2.69 GB hic
OMIX004825-08 Muscle_TM4_HiC 1 Other Type of Genomic Data 3.43 GB hic
OMIX004825-09 Muscle_BF4_HiC 1 Other Type of Genomic Data 3.49 GB hic
OMIX004825-10 Muscle_BM5_HiC 1 Other Type of Genomic Data 3.55 GB hic
OMIX004825-11 Muscle_TF4_HiC 1 Other Type of Genomic Data 3.53 GB hic
OMIX004825-12 Brain_BM4_HiC 1 Other Type of Genomic Data 2.82 GB hic
OMIX004825-13 Muscle_BF3_HiC 1 Other Type of Genomic Data 3.73 GB hic
OMIX004825-14 Brain_BM5_HiC 1 Other Type of Genomic Data 2.56 GB hic
OMIX004825-15 Brain_TM4_HiC 1 Other Type of Genomic Data 2.58 GB hic
OMIX004825-16 Brain_BF3_HiC 1 Other Type of Genomic Data 3.07 GB hic
OMIX004825-17 Liver_BF3_HiC 1 Other Type of Genomic Data 2.75 GB hic
OMIX004825-18 Haplotype_H3K27ac 12 Other Type of Genomic Data 524.71 MB zip
OMIX004825-19 Brain_TF5_HiC 1 Other Type of Genomic Data 2.51 GB hic
OMIX004825-20 Muscle_TF5_HiC 1 Other Type of Genomic Data 3.48 GB hic
OMIX004825-21 Haplotype_RNA_seq 12 Other Type of Genomic Data 654.53 MB zip
OMIX004825-22 Haplotype_H3K4me3 12 Other Type of Genomic Data 447.63 MB zip
OMIX004825-23 Liver_BF4_HiC 1 Other Type of Genomic Data 2.74 GB hic
OMIX004825-24 Musce_TM3_HiC 1 Other Type of Genomic Data 3.67 GB hic
OMIX004825-25 Liver_TF4_HiC 1 Other Type of Genomic Data 2.7 GB hic
OMIX004825-26 Liver_TF5_HiC 1 Other Type of Genomic Data 2.8 GB hic
OMIX004825-27 Liver_BM5_HiC 1 Other Type of Genomic Data 2.86 GB hic
3Relevant Publications
Paper Title Journal Name Publish Time Accession Citing Type
Haplotype-resolved 3D chromatin architecture of the hybrid pig Genome Research 2024-03 OMIX004825 Deposit

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