| Title | Single cell analysis revealed immune heterogeneity and its association with disease activity in rheumatoid arthritis |
|---|---|
| Description | Rheumatoid arthritis (RA) is a chronic, inflammatory, systemic autoimmune disease characterized by cartilage, bone damage, synovial inflammation, hyperplasia production of autoantibodies and systemic features. To gain an overall profiling of RA immune environment and its association with clinical data, we performed single cell transcriptome and VDJ sequencing on the mononuclear cells from peripheral blood (PBMC) and synovial fluid (SF) for two patients with anti-citrullinated protein autoantibodies (ACPA) high and low respectively. |
| Organism | Homo sapiens |
| Data Type | Expression Profiling |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA022090 |
| Release Date | 2026-01-06 |
| Submitter | Xiaofan Mao (xiaofanmao@126.com) |
| Organization | The First People's Hospital of Foshan |
| Submission Date | 2023-12-15 |
The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX005381-01 | Integrated Seurat object | 4 | Expression Profiling | 1.63 GB | rds | Unavailable |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Integration of single-cell and bulk RNA sequencing revealed immune heterogeneity and its association with disease activity in rheumatoid arthritis patients | Immunologic Research | 2024-07 | OMIX005381 | Deposit |