| Title |
Single-cell sequencing reveals alterations in the PBMC landscape and monocyte status during colorectal adenocarcinoma formation |
| Description |
We screened 5 healthy subjects, 5 adenoma patients and 5 early-stage adenocarcinoma patients who met the inclusion and exclusion criteria of endoscopic and pathological results. PBMC isolation and single-cell sequencing were performed using the peripheral blood from the patients. Further analysis was carried out on cell subsets. The PBMC scRNA-seq data were subjected to quality control. Expression of mitochondrial genes was concentrated in a certain area (less than 10% of the total number of genes) . After filtering of cells with a high mitochondrial gene ratio and a high erythrocyte gene ratio, a total of 110916 cells from 15 samples were analysed. |
| Organism |
Homo sapiens |
| Data Type |
Expression Profiling |
| Data Accessibility |
Controlled-access |
| BioProject |
PRJCA021923 |
| Release Date |
2024-03-26 |
| Submitter |
Jiasheng Xu (1821286450@qq.com) |
| Organization |
The Second Affiliated Hospital, Zhejiang University School of Medicine |
| Submission Date |
2024-01-22 |