SPP1+ TAM regulates the metastatic colonization of CXCR4+ metastasis-associated tumor cells by remodeling the lymph node microenvironment.
| Title | SPP1+ TAM regulates the metastatic colonization of CXCR4+ metastasis-associated tumor cells by remodeling the lymph node microenvironment. |
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| Description | Lymph node metastasis, the first stop for distant metastasis, is a primary factor contributing to mortality in patients with oral squamous cell carcinoma (OSCC). However, the underlying mechanisms of lymph node metastasis in OSCC are yet to be fully elucidated. Here, we analyzed the transcriptomes of 56,383 single cells derived from paired tissues of six OSCC patients. We found that CXCR4+ epithelial cells, identified as highly malignant disseminated tumor cells (DTCs), exhibited a propensity for lymph node metastasis. Importantly, we discovered a distinct subset of tumor-associated macrophages (TAMs) characterized by exclusive expression of phosphoprotein 1 (SPP1). These TAMs may remodel the metastatic lymph node microenvironment by potentially activating fibroblasts and promoting T cell exhaustion through SPP1-CD44 and CD155-CD226 ligand-receptor interactions, thereby facilitating colonization and proliferation of disseminated tumor cells. |
| Organism | Homo sapiens |
| Data Type | Expression Profiling by NGS |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA024831 |
| Release Date | 2024-09-30 |
| Submitter | Mingzhu Yin (yinmingzhu2008@126.com) |
| Organization | Chongqing University Three Gorges Hospital |
| Submission Date | 2024-04-01 |
The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX006117-01 | rawdata | 18 | Expression Profiling by NGS | 343.03 MB | zip | 0 | Unavailable |