| Title |
NatA Complex-mediated Acetylation Promotes the Tolerance of Phytopathogenic Fungus Verticillium dahliae to Biocontrol Bacterium |
| Description |
Here, we identified that the Bacillus amyloliquefaciens strain TG1-2 demonstrated broad-spectrum antimicrobial activity against various phytopathogens. Further exploration revealed that surfactins are the primary compounds responsible for this antimicrobial effect. A genetic screen in the phytopathogenic fungus Verticillium dahliae showed that the NatA acetyltransferase complex plays a crucial role in promoting fungal tolerance by counteracting TG1-2-induced apoptosis. Notably, TG1-2 treatment significantly inhibited the Nat A complex-mediated acetylation, enhancing fungal apoptosis. In summary, our study uncovers a novel antagonistic mechanism employed by phytopathogenic fungus to resist biocontrol bacteria, providing new targets and a theoretical foundation for enhancing the effectiveness of biocontrol bacteria in developing biopesticides against phytopathogenic fungi. |
| Organism |
Verticillium dahliae |
| Data Type |
Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility |
Open-access |
| BioProject |
PRJCA028780 |
| Release Date |
2024-08-03 |
| Submitter |
Yingchao Zhang (1037896629@qq.com) |
| Organization |
CAS Center for Excellence in Molecular Plant Sciences / Institute of Plant Physiology and Ecology |
| Submission Date |
2024-08-02 |