NatA Complex-mediated Acetylation Promotes the Tolerance of Phytopathogenic Fungus Verticillium dahliae to Biocontrol Bacterium
| Title | NatA Complex-mediated Acetylation Promotes the Tolerance of Phytopathogenic Fungus Verticillium dahliae to Biocontrol Bacterium |
|---|---|
| Description | Here, we identified that the Bacillus amyloliquefaciens strain TG1-2 demonstrated broad-spectrum antimicrobial activity against various phytopathogens. Further exploration revealed that surfactins are the primary compounds responsible for this antimicrobial effect. A genetic screen in the phytopathogenic fungus Verticillium dahliae showed that the NatA acetyltransferase complex plays a crucial role in promoting fungal tolerance by counteracting TG1-2-induced apoptosis. Notably, TG1-2 treatment significantly inhibited the Nat A complex-mediated acetylation, enhancing fungal apoptosis. In summary, our study uncovers a novel antagonistic mechanism employed by phytopathogenic fungus to resist biocontrol bacteria, providing new targets and a theoretical foundation for enhancing the effectiveness of biocontrol bacteria in developing biopesticides against phytopathogenic fungi. |
| Organism | Verticillium dahliae |
| Data Type | Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA028780 |
| Release Date | 2024-08-03 |
| Submitter | Yingchao Zhang (1037896629@qq.com) |
| Organization | CAS Center for Excellence in Molecular Plant Sciences / Institute of Plant Physiology and Ecology |
| Submission Date | 2024-08-02 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX007062-01 | TG1-2 replicate 1 | 14 | Metabolome Data by Mass Spectrometry (MS) | 634.43 MB | zip | 0 | |
| OMIX007062-02 | DH5a replicate_2 | 14 | Metabolome Data by Mass Spectrometry (MS) | 629.22 MB | zip | 0 | |
| OMIX007062-03 | TG1-2 replicate 2 | 14 | Metabolome Data by Mass Spectrometry (MS) | 467.22 MB | zip | 0 | |
| OMIX007062-04 | DH5a replicate_1 | 14 | Metabolome Data by Mass Spectrometry (MS) | 445.64 MB | zip | 0 |