| Title | Celastrol reduces cisplatin-induced nephrotoxicity in kidney organoids derived from human iPSCs |
|---|---|
| Description | We investigated the ability of celastrol to reduce cisplatin-induced nephrotoxicity using kidney organoids. RNA-seq analyses were performed to determine the mechanisms of celastrol function in the kidney. Four groups of samples were conducted to be compared based on transcriptional level, including 50 μM cisplatin treated, 2 μM celastrol treated, 2 μM celastrol plus 50 μM cisplatin treated, and control samples. |
| Organism | Homo sapiens |
| Data Type | Expression Profiling |
| Data Accessibility | Open-access |
| BioProject | PRJCA028950 |
| Release Date | 2025-03-23 |
| Submitter | Qizheng Wang (wang_qizheng@gibh.ac.cn) |
| Organization | Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences |
| Submission Date | 2024-08-08 |
HTTP download speed may be slow. It is highly recommended that you download the dataset using a dedicated FTP tool (such as FileZilla Client).
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX007089-01 | BulkRNAseq_genecount_for_Submit | 12 | Expression Profiling | 1.5 MB | csv |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Celastrol reduces cisplatin-induced nephrotoxicity by downregulating SNORD3A level in kidney organoids derived from human iPSCs | Frontiers in Pharmacology | 2025-03 | OMIX007089 | Deposit |