| Title | Intratumoral bacteria Brevibacillus parabrevis in hepatocellular carcinoma enhances antitumor immunity by inhibiting NK cell ferroptosis |
|---|---|
| Description | Results: Here, we found that the intratumoral bacteria Brevibacillus parabrevis (B. parabrevis) inhibited NK cell ferroptosis by promoting lipolysis into acetyl-CoA. Mechanistically, B. parabrevis catalyzed the acetylation of RORC, enhancing its binding to the NEDD4L promoter. NEDD4L induced ubiquitination of iron transporters SLC39A14, SLC39A8, and STEAP3. Functionally, B. parabrevis induced NK cells to differentiate into adaptability, cytotoxicity, and heat shock, inhibiting the terminal phenotype and changing the tumor microenvironment from cold to hot. |
| Organism | Homo sapiens |
| Data Type | Raman Spectra Data |
| Data Accessibility | Open-access |
| BioProject | PRJCA029034 |
| Release Date | 2024-12-31 |
| Submitter | Banglun Pan (1335563838@qq.com) |
| Organization | Fujian Medical University Union Hospital |
| Submission Date | 2024-08-12 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX007101-01 | Raw mass spectrometry data | 1 | Raman Spectra Data | 37.79 MB | fasta | |
| OMIX007101-02 | Identification of protein | 1 | Raman Spectra Data | 394.06 KB | xlsx | |
| OMIX007101-03 | Identification of peptides | 1 | Raman Spectra Data | 3.41 MB | xlsx |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Intratumoral Brevibacillus parabrevis enhances antitumor immunity by inhibiting NK cell ferroptosis in hepatocellular carcinoma | Cell Death & Disease | 2025-05 | OMIX007105 OMIX007104 OMIX007101 | Deposit |
| N-glycosylated LTβR increases the Th17/Treg cell ratio in liver cancer by blocking RORC ubiquitination and FOXP3 transcription | Cell Death & Disease | 2025-05 | OMIX008431 OMIX007101 | Deposit |