Intratumoral bacteria Brevibacillus parabrevis in hepatocellular carcinoma enhances antitumor immunity by inhibiting NK cell ferroptosis_CyTOF_C57BL/6J mouse
| Title | Intratumoral bacteria Brevibacillus parabrevis in hepatocellular carcinoma enhances antitumor immunity by inhibiting NK cell ferroptosis_CyTOF_C57BL/6J mouse |
|---|---|
| Description | Here, we found that the intratumoral bacteria Brevibacillus parabrevis (B. parabrevis) inhibited NK cell ferroptosis by promoting lipolysis into acetyl-CoA. Mechanistically, B. parabrevis catalyzed the acetylation of RORC, enhancing its binding to the NEDD4L promoter. NEDD4L induced ubiquitination of iron transporters SLC39A14, SLC39A8, and STEAP3. Functionally, B. parabrevis induced NK cells to differentiate into adaptability, cytotoxicity, and heat shock, inhibiting the terminal phenotype and changing the tumor microenvironment from cold to hot. |
| Organism | Mus musculus |
| Data Type | Flow Cytometry |
| Data Accessibility | Open-access |
| BioProject | PRJCA029040 |
| Release Date | 2024-10-12 |
| Submitter | Banglun Pan (1335563838@qq.com) |
| Organization | Fujian Medical University Union Hospital |
| Submission Date | 2024-08-12 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX007105-01 | CyTOF_C57BL6J | 1 | Flow Cytometry | 10.17 GB | zip | 0 |