Circulating Tumor DNA for Molecular Residual Disease Detection in Epithelial Ovarian Cancer
| Title | Circulating Tumor DNA for Molecular Residual Disease Detection in Epithelial Ovarian Cancer |
|---|---|
| Description | This project investigates the use of circulating tumor DNA (ctDNA) for the detection of molecular residual disease (MRD) in patients with epithelial ovarian cancer (EOC) who have undergone primary debulking surgery and adjuvant chemotherapy. Despite standard treatments, EOC patients often face relapse, highlighting the need for effective post-treatment monitoring. By analyzing ctDNA in plasma samples collected before and after treatment, alongside tumor tissue sequencing, we aim to identify tumor-specific genetic variants that could serve as early warning signs for potential relapse. This approach has the potential to improve post-operative surveillance and contribute to more personalized treatment strategies for EOC patients. |
| Organism | Homo sapiens |
| Data Type | Other Type of Genomic Data |
| Data Accessibility | Open-access |
| BioProject | PRJCA029849 |
| Release Date | 2024-11-18 |
| Submitter | Yang Xiang (xiangy@pumch.cn) |
| Organization | Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College |
| Submission Date | 2024-09-04 |
The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX007276-01 | Mutation list of 51 epithelial ovarian cancer tissues | 1 | Other Type of Genomic Data | 24.7 KB | txt | 0 | Unavailable |
| OMIX007276-02 | Mutation list of baseline blood | 1 | Other Type of Genomic Data | 16.6 KB | txt | 0 | Unavailable |
| OMIX007276-03 | Mutation list of post-surgery blood | 1 | Other Type of Genomic Data | 2.6 KB | txt | 0 | Unavailable |
| OMIX007276-04 | Mutation list of post-adjuvant chemotherapy blood | 1 | Other Type of Genomic Data | 718 bytes | txt | 0 | Unavailable |