| Title | Spop Deficiency Impairs Adipogenesis and Promotes Thermogenic Capacity in Mice |
|---|---|
| Description | As the adaptor protein that determines substrate specificity of the Cul3-SPOP-Rbx1 E3 ligase complex, SPOP is involved in numerous biological processes. However, its physiological connections with adipogenesis and thermogenesis remain poorly understood. In the current study, we report that the conditional knockout of Spop in mice results in substantial changes in protein expression, including the upregulation of a critical factor associated with thermogenesis, UCP1. Loss of SPOP also led to defects in body weight gain. In addition, conditional knockout mice exhibited resistance to high-fat-diet-induced obesity. Proteomics analysis found that proteins upregulated in the knockout mice are primarily enriched for functions in glycolysis/gluconeogenesis, oxidative phosphorylation, and thermogenesis. |
| Organism | Mus musculus |
| Data Type | Other Type of Proteomic Data |
| Data Accessibility | Open-access |
| BioProject | PRJCA032905 |
| Release Date | 2024-11-28 |
| Submitter | DanLi Song (Delicsong@126.com) |
| Organization | Graduate school of Chinese Academy of agricultural sciences |
| Submission Date | 2024-11-27 |
HTTP download speed may be slow. It is highly recommended that you download the dataset using a dedicated FTP tool (such as FileZilla Client).
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX008027-01 | FA177___Kidney.zip | 9 | Other Type of Proteomic Data | 21.55 GB | zip | |
| OMIX008027-02 | HD306___liver.zip | 10 | Other Type of Proteomic Data | 15.3 GB | zip |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Spop deficiency impairs adipogenesis and promotes thermogenic capacity in mice | PLoS Genetics | 2024-12 | OMIX008027 OMIX006787 OMIX004443 | Deposit |