OMIX004443

1Summary
Title Plasma metabolic signatures uncover therapeutic response and prognosis of third-generation EGFR-TKI treatment in patients with NSCLC-the metabolic data
Description Advanced EGFR T790M-mutated non-small cell lung cancer (NSCLC) inevitably develops resistance to third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs) therapy. Metabolic reprogramming support EGFR-TKI resistance, while thorough metabolomics clinical studies are limited. Here, we enrolled 186 NSCLC patients from Phase I and IIa clinical studies and characterized responsive metabolic features of third-generation EGFR-TKI. Our study included locally advanced or metastatic NSCLC patients from the open-label, single-arm, phase I/IIa study of BPI-7711(NCT03386955). Tumor diagnosis was confirmed by histology or cytology, with EGFR-sensitive mutations (including Exon19Deletion, L858R, G719X, L861QandS768I). Two hundred and twenty plasma samples of 186 patients were collected in 16 hospitals (220 for metabolism,49 for WES and 14 for proteomics).
Organism Homo sapiens
Data Type Metabolome Data by Mass Spectrometry (MS)
Data Accessibility Controlled-access
BioProject PRJCA018003
Release Date 2024-07-01
Submitter Yuankai Shi (syuankaipumc@126.com)
Organization National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences
Submission Date 2023-06-29
Request for this Data
2Files & Download

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File ID File Title Number/Samples File Type File Size File Suffix Download
OMIX004443-01 The normalized metabolic data of plasma samples 1 Metabolome Data by Mass Spectrometry (MS) 4.2 MB xlsx Controlled
OMIX004443-02 The sample list of metabolism detection 1 Metabolome Data by Mass Spectrometry (MS) 15.7 KB xlsx Controlled
OMIX004443-03 sample-1 1 Metabolome Data by Mass Spectrometry (MS) 23.4 MB raw Controlled
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3Relevant Publications
Paper Title Journal Name Publish Time Accession Citing Type
Plasma metabolomics profiling of EGFR-mutant NSCLC patients treated with third-generation EGFR-TKI Scientific Data 2024-11 OMIX006787 OMIX004443 Deposit
Spop deficiency impairs adipogenesis and promotes thermogenic capacity in mice PLoS Genetics 2024-12 OMIX008027 OMIX006787 OMIX004443 Deposit

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