| Title | Gut Microbiota Dysbiosis and Metabolomic Alterations in Patients with Calcium Oxalate Kidney Stone |
|---|---|
| Description | A total of 193 patients with CaOx kidney stones and 99 healthy volunteers were recruited from the First People's Hospital of Yulin and the Second Nanning People's Hospital between April and September 2022. Peripheral venous blood, second midstream urine, and stool samples were collected in the morning while fasting. Samples were stored at 4°C immediately after collection and transferred to -80°C within 2 hours. Metabolomic profiling: A liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) system was used to analyze metabolites in 291 plasma samples (192 CaOx stone patients and 99 healthy controls). To maximize metabolite detection, hydrophilic and hydrophobic metabolites were separately extracted and analyzed. Additionally, widely targeted metabolomics was performed on 286 fecal samples (188 CaOx stone patients and 98 healthy controls), and 292 urinary samples (193 CaOx stone patients and 99 healthy controls) using the LC-MS/MS platform. |
| Organism | Homo sapiens |
| Data Type | Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA032222 |
| Release Date | 2026-01-02 |
| Submitter | Zengnan Mo (mozengnan@gxmu.edu.cn) |
| Organization | Guangxi Medical University |
| Submission Date | 2024-12-24 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX008393-01 | Widely targeted metabolomics of 286 fecal samples (188 CaOx stone patients and 98 healthy controls) | 572 | Metabolome Data by Mass Spectrometry (MS) | 410.15 MB | zip | Controlled |
| OMIX008393-02 | Widely targeted metabolomics of 292 urinary samples (193 CaOx stone patients and 99 healthy controls) | 584 | Metabolome Data by Mass Spectrometry (MS) | 417.52 MB | zip | Controlled |
| OMIX008393-03 | Widely targeted metabolomics of 291 plasma samples (192 CaOx stone patients and 99 healthy controls). | 582 | Metabolome Data by Mass Spectrometry (MS) | 398.42 MB | zip | Controlled |
| OMIX008393-04 | Widely targeted lipidomics of 291 plasma samples (192 CaOx stone patients and 99 healthy controls). | 582 | Metabolome Data by Mass Spectrometry (MS) | 310.6 MB | zip | Controlled |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Dysbiosis of the gut microbiota in calcium oxalate nephrolithiasis is associated with impaired short-chain fatty acid production and systemic metabolomic disruptions | Microbiome | 2025-12 | OMIX008393 | Deposit |