| Title | lncRNA IL6-AS1 promotes inflammatory effects in lung macrophages via exosomes through the S100A9/TLR4 pathway in COPD progression |
|---|---|
| Description | This study investigates the role of IL6-AS1, a highly expressed long non-coding RNA (lncRNA), in chronic obstructive pulmonary disease (COPD). An adeno-associated virus (AAV) was used to induce the expression of IL6-AS1 in mice, and they were exposed to cigarette smoke to establish a COPD model. Our findings indicate that the upregulation of IL6-AS1 in fibroblasts enhances the interaction between the S100A9 protein and the AGER and TLR4 receptors on lung macrophages, thereby exacerbating inflammatory responses. These findings suggest that IL6-AS1 may play a role in facilitating the crosstalk between fibroblasts and macrophages, leading to increased pulmonary inflammation. Mendelian randomization analysis further suggests a potential shared causal variant between IL6-AS1 and COPD. Taken together, this investigation provides valuable insights into the function of IL6-AS1 and its potential implications for the pathogenesis and therapeutic strategies in COPD. |
| Organism | Homo sapiens |
| Data Type | Proteomic Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA034467 |
| Release Date | 2025-07-21 |
| Submitter | Erkang Yi (188648614@qq.com) |
| Organization | Guangzhou Laboratory |
| Submission Date | 2025-01-02 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX008538-01 | LacZ-protein-peptides | 1 | Proteomic Data by Mass Spectrometry (MS) | 87.3 KB | csv | |
| OMIX008538-02 | IL6-AS1-protein-peptides | 1 | Proteomic Data by Mass Spectrometry (MS) | 136.8 KB | csv |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Long Noncoding RNA Interleukin 6 Antisense RNA 1 Promotes Inflammatory Effects in Lung Macrophages via Exosomes Through the S100A9/TLR4 Pathway in Chronic Obstructive Pulmonary Disease Progression | MedComm | 2025-06 | OMIX008537 OMIX008536 OMIX008538 | Deposit |