| Title |
The Role of METTL3 in Transposable Elements Regulation and 2C-like Program Induction in Mouse Embryonic Stem Cell |
| Description |
METTL3 KO in mESCs upregulates most TEs and 2C-like genes via m6A-dependent mechanisms, regardless of culture. Transient METTL3 degradation enables METTL3-deficient mESCs to contribute to trophectoderm lineages in chimeras, indicating expanded developmental potential. This demonstrates METTL3-mediated m6A modifications regulate mESC transcriptional and developmental plasticity, linking m6A loss to an extended potency state resembling the 2C-like program. |
| Organism |
Mus musculus |
| Data Type |
Expression Profiling |
| Data Accessibility |
Open-access |
| BioProject |
PRJCA040908 |
| Release Date |
2025-12-03 |
| Submitter |
Jiekai Chen (chen_jiekai@gibh.ac.cn) |
| Organization |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences |
| Submission Date |
2025-06-01 |