| Title | Genomic pathogenic alterations in the SWI/SNF complex compromise the outcomes of immunotherapy in Chinese patients with KRAS-mutant NSCLC by downregulating STING expression |
|---|---|
| Description | Investigation of SWI/SNF complex gene mutations in KRAS-mutant non-small cell lung cancer (NSCLC) and their association with immune checkpoint blockade (ICB) response. Includes genomic and transcriptomic (RNA-seq) analyses to identify prognostic markers and potential mechanisms, such as STING pathway modulation. |
| Organism | Homo sapiens |
| Data Type | Expression Profiling |
| Data Accessibility | Open-access |
| BioProject | PRJCA041569 |
| Release Date | 2025-08-08 |
| Submitter | Xuchao Zhang (zhxuchao3000@126.com) |
| Organization | Guangdong Provincial People's Hospital |
| Submission Date | 2025-06-13 |
HTTP download speed may be slow. It is highly recommended that you download the dataset using a dedicated FTP tool (such as FileZilla Client).
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX010537-01 | patients_NGS_results | 922 | Expression Profiling | 1.7 MB | xlsx | |
| OMIX010537-02 | cell_WES_results | 7 | Expression Profiling | 140.6 MB | xlsx | |
| OMIX010537-03 | cell_RNAseq_results | 7 | Expression Profiling | 8.1 MB | xls |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Genomic pathogenic alterations in the SWI/SNF complex compromise the outcomes of immunotherapy in Chinese patients with KRAS-mutant NSCLC by downregulating STING expression | BMC Medicine | 2025-12 | OMIX010537 | Deposit |