| Title |
SLC6A19-Mediated Tryptophan Uptake Suppresses Renal Cell Carcinoma Metastasis via Activating NAD+-Dependent Deacetylase SIRT1 |
| Description |
Metastasis is the hallmark of lethal renal cell carcinoma (RCC), and the underlying mechanism driving RCC metastasis remains insufficiently understood. Amino acid metabolism remodeling plays a key role in the matastasis of RCC. In this study, we identified SLC6A19, a tryptophan transporter, as a novel suppressor gene of RCC, which is closely correlated with the metastasis and survival of RCC patients. Overexpression of SLC6A19 significantly inhibits RCC cell proliferation, migration and invasion both in vitro and in vivo. In conclusion, this study uncovers a novel key pathway that drives RCC invasion and metastasis, offering a promising therapeutic target for clinical intervention. |
| Organism |
Homo sapiens |
| Data Type |
Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility |
Controlled-access |
| BioProject |
PRJCA043478 |
| Release Date |
2025-09-19 |
| Submitter |
Changwei Ji (jichangwei@nju.edu.cn) |
| Organization |
Department of Urology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Institute of Urology, Nanjing University |
| Submission Date |
2025-07-21 |