| Title | LC-MS/MS analysis of the artical named "Timing Matters: Nighttime-restricted Feeding Disrupts Spermatogenesis via Gut Microbiota-Derived KYNA homeostasis" |
|---|---|
| Description | Time-restricted feeding (TRF) shows promise in affecting body metabolic homeostasis by modulating circadian rhythms, but its effects on male fertility remain largely unexplored. This study aimed to investigate how different TRF patterns influence testicular homeostasis and spermatogenesis, specifically focusing on the role of gut microbiota and its metabolites within the "gut-testis" axis. We compared two groups of mice: those on a daytime-restricted feeding (DRF) schedule and those on a nighttime-restricted feeding (NRF) schedule, against a control group (Ctr) that had ad libitum access to food. We observed a significant reduction in testicular index and sperm quality in the NRF group; no impacts were found in the DRF group. Histological analysis confirmed a decreased number of spermatocytes and spermatozoa in NRF group. |
| Organism | Mus musculus |
| Data Type | Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA044527 |
| Release Date | 2025-12-18 |
| Submitter | Donghui Yang (17792612916@163.com) |
| Organization | Sichuan Agricultural University |
| Submission Date | 2025-08-10 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX011413-01 | DRF_1 | 1 | Metabolome Data by Mass Spectrometry (MS) | 70.48 MB | zip | |
| OMIX011413-02 | NRF_1 | 1 | Metabolome Data by Mass Spectrometry (MS) | 71.64 MB | zip | |
| OMIX011413-03 | NRF_2 | 1 | Metabolome Data by Mass Spectrometry (MS) | 71.01 MB | zip | |
| OMIX011413-04 | DRF_2 | 1 | Metabolome Data by Mass Spectrometry (MS) | 70.54 MB | zip | |
| OMIX011413-05 | CTRL_1 | 1 | Metabolome Data by Mass Spectrometry (MS) | 69.79 MB | zip | |
| OMIX011413-06 | CTRL_2 | 1 | Metabolome Data by Mass Spectrometry (MS) | 71.14 MB | zip | |
| OMIX011413-07 | DRF_3 | 1 | Metabolome Data by Mass Spectrometry (MS) | 71.53 MB | zip | |
| OMIX011413-08 | NRF_3 | 1 | Metabolome Data by Mass Spectrometry (MS) | 69.69 MB | zip | |
| OMIX011413-09 | DRF_4 | 1 | Metabolome Data by Mass Spectrometry (MS) | 71.1 MB | zip | |
| OMIX011413-10 | CTRL_3 | 1 | Metabolome Data by Mass Spectrometry (MS) | 70.71 MB | zip | |
| OMIX011413-11 | NRF_4 | 1 | Metabolome Data by Mass Spectrometry (MS) | 70.79 MB | zip | |
| OMIX011413-12 | CTRL_4 | 1 | Metabolome Data by Mass Spectrometry (MS) | 71.86 MB | zip |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Nighttime-restricted feeding disrupts spermatogenesis in mice via gut microbiota-derived KYNA homeostasis | Communications Biology | 2026-02 | OMIX011413 | Deposit |