OMIX011441

1Summary
Title Untargeted metabolomics and mass spectrometry of peripheral blood monocytes in human subjects
Description In order to undertake a systematic investigation into the metabolism of monocytes in atherosclerosis, an untargeted metabolomic profiling of peripheral blood monocytes was performed from patients who were positive for thin-cap fibroatheroma (TCFA) (n=38) in comparison to patients who were negative for TCFA (n=38). The investigation was conducted using a method of mass spectrometry, with the objective of examining the methionine metabolism of monocytes from patients who were TCFA-positive, in comparison to patients who were TCFA-negative. This investigation was performed in both the discovery cohort (n=76) and the validation cohort (n=200).
Organism Homo sapiens
Data Type Other Type of Metabolome Data
Data Accessibility Open-access
BioProject PRJCA044688
Release Date 2025-10-07
Submitter ping sun (sunpinghmu@163.com)
Organization Harbin Medical University
Submission Date 2025-08-13
2Files & Download

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File ID File Title Number/Samples File Type File Size File Suffix Download
OMIX011441-02 Untargeted metabolomics-TCFA-negative 38 Other Type of Metabolome Data 59.4 KB xlsx
OMIX011441-03 Untargeted metabolomics-TCFA-positive 38 Other Type of Metabolome Data 59.9 KB xlsx
OMIX011441-04 Mass spectrometry-76 76 Other Type of Metabolome Data 17.7 KB xlsx
OMIX011441-05 Mass spectrometry-200 200 Other Type of Metabolome Data 16.7 KB xlsx
3Relevant Publications
Paper Title Journal Name Publish Time Accession Citing Type
MAT2A promotes atherosclerotic plaque vulnerability by mediating epigenetic reprogramming of macrophages Nature Communications 2025-12 OMIX011441 Deposit

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