| Title |
Extensive ancestral gene flow and complex evolutionary dynamics among eastern Tibetan Plateau populations |
| Description |
The origins of Tibeto-Burman populations inhabiting the eastern Tibetan Plateau (TP), particularly within the Tibetan-Yi Corridor, remain elusive. To reconstruct the regional complex peopling history, we performed whole-genome sequencing of 293 individuals from 21 Tibeto-Burman-speaking populations and genotyped 799 individuals from 60 Sino-Tibetan-speaking populations. Our analyses reveal fine-scale population substructure and extensive admixture along the underrepresented Tibetan-Yi and Hexi corridors, driven by substantial gene flow from Eastern Eurasian rice/millet farmers and Western Eurasian steppe pastoralists. We estimate that Tibetans diverged from their common ancestors with Han Chinese during the early Neolithic (~9.9 kya), followed by a middle Neolithic differentiation within Tibetan-Yi Corridor populations between ~1.2 and ~4.6 kya. These divergence events coincide with distinct cultural trajectories that shaped the north-south genetic structure of Tibeto-Burman groups. |
| Organism |
Homo sapiens |
| Data Type |
Other Type of Genomic Data |
| Data Accessibility |
Controlled-access |
| BioProject |
PRJCA040062 |
| Release Date |
2025-12-03 |
| Submitter |
Guanglin He (Guanglinhescu@163.com) |
| Organization |
Institute of Rare Diseases, West China Hospital of Sichuan University |
| Submission Date |
2025-09-06 |