| Title |
Transcriptomic Analysis of Chemoresistance in Prostate Cancer Cells under Different Stiffness Conditions |
| Description |
Chemoresistance remains a major challenge in prostate cancer therapy. Higher Gleason scores in clinical samples are associated with increased matrix stiffness in prostate cancer tissues. By culturing prostate cancer cells on polyacrylamide hydrogels, it has been found that stiffness enhances chemoresistance in prostate cancer cells. However, the specific mechanisms by which stiffness regulates chemoresistance are not yet fully understood. Here, we use RNA-seq to further characterize the transcriptomic changes underlying stiffness-driven chemoresistance. |
| Organism |
Homo sapiens |
| Data Type |
Expression Profiling |
| Data Accessibility |
Controlled-access |
| BioProject |
PRJCA048572 |
| Release Date |
2025-10-20 |
| Submitter |
Peng Wu (wupeng29@mail2.sysu.edu.cn) |
| Organization |
School of Medicine, Sun Yat-sen University |
| Submission Date |
2025-10-18 |