| Title |
Metabolomic impact of maternal barium exposure on miscarriage |
| Description |
This project investigates the metabolic mechanisms underlying the association between maternal exposure to barium (Ba) and miscarriage. A total of 186 pregnant women were recruited, and both blood Ba levels and decidual tissue metabolomic profiles were analyzed using UHPLC-QExactiveHF-X mass spectrometry. Metabolome-wide association and mediation analyses identified key metabolites and pathways, including glycerophospholipid metabolism and oxidative stress-related metabolites. Five core metabolites were further used to construct a machine learning-based risk prediction model for miscarriage. The study provides new insights into environmental pollutant-induced reproductive toxicity and potential biomarkers for early miscarriage risk assessment. |
| Organism |
Homo |
| Data Type |
Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility |
Controlled-access |
| BioProject |
PRJCA049342 |
| Release Date |
2026-01-03 |
| Submitter |
Qing Xu (xuqing@njmu.edu.cn) |
| Organization |
Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital |
| Submission Date |
2025-10-28 |