| Title | Identification of altered immune landscape at single-cell resolution and its association with poor immune checkpoint inhibitor responses in NSCLC brain metastasis |
|---|---|
| Description | Brain metastasis, a common complication of advanced non-small cell lung cancer (NSCLC), leads to poor prognosis and reduces the efficacy of immune checkpoint inhibitors (ICIs). However, the mechanisms underlying this diminished ICI response remain unclear. Therefore, we comprehensively analyzed RNA sequencing data derived from immune cells isolated from primary and brain metastatic NSCLC single-cell samples. |
| Organism | Homo sapiens |
| Data Type | Expression Profiling |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA037797 |
| Release Date | 2026-03-04 |
| Submitter | Tengfeifei Teng (tengfeifei16@126.com) |
| Organization | Shandong Cancer Hospital and Institute |
| Submission Date | 2026-02-23 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX015258-01 | P1 | 1 | Expression Profiling | 47.9 MB | gz | Controlled |
| OMIX015258-02 | P2 | 1 | Expression Profiling | 34.3 MB | gz | Controlled |
| OMIX015258-03 | P3 | 1 | Expression Profiling | 32.5 MB | gz | Controlled |
| OMIX015258-04 | P4 | 1 | Expression Profiling | 41.6 MB | gz | Controlled |
| OMIX015258-05 | P5 | 1 | Expression Profiling | 30.0 MB | gz | Controlled |
| OMIX015258-06 | P6 | 1 | Expression Profiling | 28.3 MB | gz | Controlled |
| OMIX015258-07 | P7 | 1 | Expression Profiling | 28.4 MB | gz | Controlled |
| OMIX015258-08 | P8 | 1 | Expression Profiling | 35.0 MB | gz | Controlled |
| OMIX015258-09 | BM1 | 1 | Expression Profiling | 15.5 MB | gz | Controlled |
| OMIX015258-10 | BM2 | 1 | Expression Profiling | 39.3 MB | gz | Controlled |
| OMIX015258-11 | BM3 | 1 | Expression Profiling | 38.3 MB | gz | Controlled |
| OMIX015258-12 | BM4 | 1 | Expression Profiling | 54.1 MB | gz | Controlled |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Identification of altered immune landscape at single-cell resolution in NSCLC brain metastasis and its association with poor immune checkpoint inhibitor responses | Nature Communications | 2026-03 | OMIX015258 | Deposit |