Epigenetic Impact of Chronic Inflammation On Colon Mucosa Cells
| Title | Epigenetic Impact of Chronic Inflammation On Colon Mucosa Cells |
|---|---|
| Description | To investigate how DNA methylation alterations contribute to inflammation-associated carcinogenesis, chronic colitis mouse model was established by dextran sodium sulfate (DSS) treated and then colon mucosa were separated for Bisulfite genomic sequencing. The methylation level was calculated based on the percentage of methylated cytosine in the whole genome, including mCG, CHG and CHH. Differentially methylated regions (DMRs) both in the upstream, downstream and genebody between DSS-treated colon mucosa (DSS) and control (CK) were identified. |
| Organism | Mus |
| Data Type | - |
| Data Accessibility | Open-access |
| BioProject | PRJCA006765 |
| Release Date | 2021-10-11 |
| Submitter | Jia He (hejia021@126.com) |
| Organization | The First People’s Hospital of Foshan |
| Submission Date | 2021-10-10 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX694-60-01 | Differentially methylated regions in CG (DSS VS. CK) | 4 | DNA Methylation | 1.2 MB | rar | 0 | |
| OMIX694-60-02 | Differentially methylated regions in CHG (DSS VS. CK) | 4 | DNA Methylation | 23.7 KB | rar | 0 | |
| OMIX694-60-03 | Differentially methylated regions in CHH(DSS VS. CK) | 4 | DNA Methylation | 326.1 KB | rar | 0 |