Elevated testicular apoptosis is associated with elevated sphingosine driven by gut microbiota in prediabetic sheep
| Title | Elevated testicular apoptosis is associated with elevated sphingosine driven by gut microbiota in prediabetic sheep |
|---|---|
| Description | Administration of melatonin alleviates the symptoms of prediabetes, especially those of impaired spermatogenesis, which results from the restoration of gut microbiota and metabolic levels of sphingosine. Our results reveal that sphingosine contributed to the disruption of spermatogenesis and could be a disease marker; furthermore, melatonin represents a potential prebiotic agent for the treatment of male infertility caused by prediabetes and its complications. |
| Organism | Ovis aries |
| Data Type | - |
| Data Accessibility | Open-access |
| BioProject | PRJCA007028 |
| Release Date | 2022-05-06 |
| Submitter | Shan Liying (1318329288@qq.com) |
| Organization | Inner Mongolia University |
| Submission Date | 2021-11-01 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX719-30-01 | Rescue | 10 | Metabonomics | 789.16 MB | mzXML | 0 | |
| OMIX719-30-02 | Prediabetes | 10 | Metabonomics | 833.95 MB | mzXML | 0 | |
| OMIX719-30-03 | Control | 10 | Metabonomics | 800.65 MB | mzXML | 0 | |
| OMIX719-30-04 | QC | 8 | Metabonomics | 639.23 MB | mzXML | 0 |