Characterization of BDE-47-induced prepubertal testicular toxicity in mice via single-cell RNA-sequencing
| Title | Characterization of BDE-47-induced prepubertal testicular toxicity in mice via single-cell RNA-sequencing |
|---|---|
| Description | Single-cell sequencing (ScRNA-seq) comprehensively determines the transcriptional sequence information of individual cells and advanced our understanding of complex biological processes at unprecedented resolution. 2,2,4,4-tetrabromodiphenyl ether (BDE-47) is a dominant congener of polybrominated diphenyl ethers (PBDEs) that have been widely used as flame-retardant additives. BDE-47 is well-established with male reproductive toxicity, but the underlying molecular mechanisms are not fully characterized. Here, ScRNA-seq was employed to dissect BDE-47-induced prepubertal testicular toxicity in mice. Our results revealed comprehensive heterogeneous information of differential expressed genes, signaling pathways, transcriptional factors, and ligand-receptors in major testis cell types upon BDE-47-treatment in mouse testis. Our results can also serve as an important resource for future dissection of BDE-47-induced male reproduction toxicity. |
| Organism | Mus musculus |
| Data Type | - |
| Data Accessibility | Open-access |
| BioProject | PRJCA007181 |
| Release Date | 2021-12-04 |
| Submitter | siyu xia (syxbestmayer@whu.edu.cn) |
| Organization | Jinan University |
| Submission Date | 2021-12-04 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX792-20-01 | BDE47_1_matrix | 1 | Transcriptomic | 129.09 MB | zip | 0 | |
| OMIX792-20-02 | BDE47_2_barcodes | 1 | Transcriptomic | 53.07 KB | zip | 0 | |
| OMIX792-20-03 | BDE47_1_features | 1 | Transcriptomic | 254.44 KB | zip | 0 | |
| OMIX792-20-04 | BDE47_1_barcodes | 1 | Transcriptomic | 55.47 KB | zip | 0 | |
| OMIX792-20-05 | BDE47_2_features | 1 | Transcriptomic | 254.44 KB | zip | 0 | |
| OMIX792-20-06 | BDE47_3_features | 1 | Transcriptomic | 254.44 KB | zip | 0 | |
| OMIX792-20-07 | Control2_features.zip | 1 | Transcriptomic | 254.44 KB | zip | 0 | |
| OMIX792-20-08 | BDE47_3_barcodes | 1 | Transcriptomic | 55.34 KB | zip | 0 | |
| OMIX792-20-09 | Control3_barcodes | 1 | Transcriptomic | 59.94 KB | zip | 0 | |
| OMIX792-20-10 | Control1_barcodes | 1 | Transcriptomic | 61.69 KB | zip | 0 | |
| OMIX792-20-11 | BDE47_2_matrix | 1 | Transcriptomic | 119.09 MB | zip | 0 | |
| OMIX792-20-13 | BDE47_3_matrix | 1 | Transcriptomic | 116.2 MB | zip | 0 | |
| OMIX792-20-14 | Control1_features | 1 | Transcriptomic | 254.44 KB | zip | 0 | |
| OMIX792-20-15 | Control2_barcodes | 1 | Transcriptomic | 53.11 KB | zip | 0 | |
| OMIX792-20-16 | Control3_features | 1 | Transcriptomic | 254.44 KB | zip | 0 |