Introduction

Haplotype assembly is becoming a very important tool in genome sequencing of human and other organisms. Although haplotypes were previously inferred from genome assemblies, there has never been a comparative haplotype browser that depicts a global picture of whole-genome alignments among haplotypes of different organisms. We introduce a whole-genome HAPLotype brOWSER (HAPLOWSER), providing evolutionary perspectives from multiple aligned haplotypes and functional annotations. Haplowser enables the comparison of haplotypes from metagenomes, and associates conserved regions or the bases at the conserved regions with functional annotations and custom tracks. The associations are quantified for further analysis and presented as pie charts. Functional annotations and custom tracks that are projected onto haplotypes are saved as multiple files in FASTA format. Haplowser provides a user-friendly interface, and can display alignments of haplotypes with functional annotations at any resolution.Haplowser, written in Java, supports multiple platforms including Windows and Linux. Haplowser is publicly available at http://embio.yonsei.ac.kr/haplowser .

Publications

  1. HAPLOWSER: a whole-genome haplotype browser for personal genome and metagenome.
    Cite this
    Kim JH, Kim WC, Waterman MS, Park S, Li LM, 2009-09-01 - Bioinformatics (Oxford, England)

Credits

  1. Jong Hyun Kim
    Developer

    Department of Genetics, Harvard Medical School, United States of America

  2. Woo-Cheol Kim
    Developer

  3. Michael S Waterman
    Developer

  4. Sanghyun Park
    Developer

  5. Lei M Li
    Investigator

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Summary
AccessionBT000171
Tool TypeApplication
Category
PlatformsLinux/Unix
Technologies
User InterfaceTerminal Command Line
Download Count0
Submitted ByLei M Li